Key cells in the brain, neurons, form networks by exchanging signals, enabling the brain to learn and adapt at incredible speed. Researchers have now developed a 3D-printed ‘brain-like environment’ where neurons grow similarly to a real brain. Using tiny nanopillars, they mimic the soft neural tissue and the brain extracellular matrix fibers. This model provides new insights into how neurons form networks, as well as a novel tool to understand in future how this process may change in neurological disorders such as Alzheimer’s, Parkinson’s disease, and autism spectrum disorders.