Early detection of disease is considered positive — but what if it finds ‘too much’? While early diagnosis can improve the chances of recovery, early detection can also have unwanted side effects. After all, not everything that is found would have become life-threatening in the course of the disease. TOSYMA, the world’s largest randomized diagnostic superiority study on early breast cancer detection, has now investigated whether the innovative DBT+SM method for early breast cancer detection also has such an effect — and was once again able to hint on advantages of the approach over the screening standard by finding more early tumor stages of tumor grades 2 and 3.