Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes — more than nine in ten — are edited by the spliceosome. The sheer number of components involved has meant the scientific feat took more than a decade to complete. The research reveals many new drug targets that could benefit a wide spectrum of diseases including most types of cancer, neurodegenerative conditions and genetic disorders.