Hundreds of novel ingredients never encountered by human physiology are now found in nearly 60 percent of the average adult’s diet and nearly 70 percent of children’s diets in the U.S. An emerging health hazard is the unprecedented consumption of these ultra-processed foods in the standard American diet. This may be the new ‘silent’ killer, as was unrecognized high blood pressure in previous decades. Physicians provide important insights in a battle where the entertainment industry, the food industry and public policy do not align with their patients’ needs.