The treatment of pancreatic cancer, an aggressive form of cancer associated with high mortality rates, is challenging owing to limited options and anticancer screening models. High mortality has been attributed to the unique tumor microenvironment (TME). Researchers have now created a pancreatic ductal adenocarcinoma (PDAC) organoid model using human-induced pluripotent stem cell (hiPSC) technology, simulating desirable TME properties. Their research findings have far-reaching consequences in the field of cancer biology.