Certain glycans — sugar-like compounds with carbohydrate chains — containing galactose, may exhibit potential prebiotic properties that support human health. Identifying enzymes capable of breaking down these glycans is essential for unlocking their full potential. In a new study, researchers discovered a novel enzyme in the human gut that specifically targets a previously unexplored glycan called -1,2-galactooligosaccharide, known for their prebiotic benefits. This discovery can open new avenues in prebiotic research, potentially enhancing human health.