In a study of more than 100,000 people, researchers found that people with a less healthy lifestyle (higher BMI, greater smoking, greater alcohol consumption, less physical activity, poorer diet quality) had a greater reduction in risk of colorectal cancer associated with aspirin use, compared to participants with a healthier lifestyle. Participants with a healthier lifestyle had a lower baseline risk of colorectal cancer, and their benefit was less pronounced. The study’s findings could encourage a more nuanced approach to preventive aspirin use.